和水平与前列腺癌患者的生存率之间的相关性
Sandra Pietrzak1, Wojciech Marciniak2, Róża Derkacz2
1Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Nutrients
|February 24, 2024
概括
优化 (Se) 和 (Zn) 水平可能会改善前列腺癌的生存率. 这项研究发现Se和Zn水平与患者的治疗结果之间存在显著的关联,这凸显了进一步研究的必要性.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 前列腺癌是男性中最常见的癌症.
- 生存率很好,但可以通过优化风险因素来提高.
- 像 (Se) 和 (Zn) 这样的微量营养素是潜在的可修改因素.
研究的目的:
- 研究最佳和水平对前列腺癌患者存活率的影响.
- 在前列腺癌预后的背景下探索Se和Zn之间的相互作用.
主要方法:
- 在338名波兰前列腺癌患者 (2009-2015) 中,使用诱导合血质谱测量了血清中Se和Zn的水平.
- 参与者根据Se和Zn水平分为四分之一.
- 考克斯回归分析被用来评估元素含量与存活率之间的关联.
主要成果:
- 结合Se和Zn水平与前列腺癌患者的存活率之间观察到显著的关联.
- 对于Se和Zn的最低与最高四分位数的危险比率 (HR) 为20.9 (SeQI-ZnQI与SeQIV-ZnQIV).
结论:
- 结合的和水平似乎影响前列腺癌患者的生存率.
- 需要进一步的研究,以建立针对癌症患者的特定人群的Se/Zn营养规范.
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