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肥胖是SARS-CoV-2患者并发症和死亡的危险因素:系统性审查
Marielle Priscila de Paula Silva-Lalucci1,2, Déborah Cristina de Souza Marques1,2, Pablo Valdés-Badilla3,4
1Interdisciplinary Laboratory of Intervention in Health Promotion, Cesumar Institute of Science, Technology, and Innovation, Maringá 87050-390, Paraná, Brazil.
超重和肥胖增加了住院COVID-19患者严重后果的风险. 这些疾病与较高的死亡率,更大的呼吸辅助需求和改变的生化标志物有关.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 超重和肥胖是全球普遍存在的健康问题.
- 超重对COVID-19严重性的影响需要全面分析.
- 糖尿病和高血压等并发症在肥胖患者中很常见.
研究的目的:
- 系统地审查关于超重/肥胖作为COVID-19结果的风险因素的研究.
- 在住院COVID-19患者中分析超重与死亡率,呼吸支和生物化学标志物之间的关联.
- 评估有关肥胖和COVID-19严重程度的证据质量.
主要方法:
- 在PubMed,Web of Science和Scopus数据库中进行系统的文献搜索,直到2024年1月.
- 包括符合PRISMA指南的研究,重点关注超重/肥胖的成年COVID-19患者.
- 使用Downs and Black工具进行质量评估.
主要成果:
- 八项涉及9782名成年人的研究符合纳入标准.
- 超过一半的住院COVID-19患者存在超重和肥胖.
- 超重/肥胖的成年人面临更高的死亡风险,重症监护室 (ICU) 的入院,以及需要呼吸支持.
- 生物化学标志物 (前素,CRP,IL-6) 的升高与该组的感染严重程度有关.
结论:
- 超重和肥胖是造成COVID-19不良结果的重要风险因素.
- 超重与增加的死亡率,需要重症监护和呼吸系统支持有关.
- 肥胖影响生物化学标记,反映了COVID-19疾病的严重程度.
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