失生症,母体免疫激活和自闭症之间:有没有共同的路径?
Maria Suprunowicz1, Natalia Tomaszek1, Agata Urbaniak1
1Department of Psychiatry, Medical University of Bialystok, pl. Wołodyjowskiego 2, 15-272 Białystok, Poland.
Nutrients
|February 24, 2024
概括
母亲肠道微生物组的变化可能会影响儿童自闭症谱系障碍 (ASD) 的发展,特别是在母体免疫激活时. 针对肠道微生物群的治疗有望减少炎症并改善自闭症症的结果.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,与肠-大脑-微生物组轴功能障碍有关.
- 肠道微生物群的异常组成和细菌产物可能导致神经炎症和ASD中大脑发育的改变.
- 短链脂肪酸 (SCFA) 和肠道透性都与ASD的发病有关.
研究的目的:
- 审查母体肠道微生物群对儿童自闭症发展的影响,考虑母体免疫激活 (MIA).
- 探索出生路线对婴儿肠道殖民化的影响.
- 在ASD中检查环境因素,如促炎性细胞因子 (IL-6,IL-17a) 和母亲肥胖症.
主要方法:
- 关于ASD肠道-大脑-微生物组轴研究的综合文献综述.
- 对母亲因素,分娩路线和环境影响的研究分析.
- 评估针对肠道微生物群的当前和新兴治疗策略.
主要成果:
- 母亲肠道微生物群的改变,MIA,分娩路线以及IL-6,IL-17a和肥胖等因素与ASD风险有关.
- 肠道功能失调和相关的炎症是ASD病变发生的关键特征.
- 诸如益生菌,益生菌和便微生物群移植等新兴疗法显示出潜力.
结论:
- 母亲的肠道微生物组在ASD的发展中起着至关重要的作用.
- 了解这些与肠道相关的因素可以为ASD提供新的治疗方法.
- 准肠道微生物群为管理ASD和相关炎症提供了一个有希望的途径.
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