在进步性多发性硬化症的动物模型中补充维生素D的性别差异
Michaela Tanja Haindl1, Muammer Üçal2, Cansu Tafrali1
1Department of Neurology, Medical University of Graz, 8010 Graz, Austria.
Nutrients
|February 24, 2024
概括
维生素D (VD) 对诸如多发性硬化症 (MS) 等自身免疫性疾病产生影响,多发性硬化症对两性影响不同. 这项研究发现,VD补充对雄性和雌性大鼠都有好处,雄性在减少MS类损伤方面显示出更大的整体改善.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 自身免疫性疾病,包括多发性硬化症 (MS),在发病率和预后上表现出与性别相关的差异.
- 维生素D (VD) 在免疫调节中起作用,其不足与自身免疫性疾病有关.
- 受静脉疾病和性激素影响的氧化应激可能导致MS中脱髓化和轴突损伤.
研究的目的:
- 在渐进性多发性硬化症 (PMS) 动物模型中研究与性别相关的差异.
- 评估维生素D (VD) 补充对雄性和雌性大鼠PMS病理学的影响.
- 探索氧化应激和抗氧化能力在性别特异性MS进展和VD反应中的作用.
主要方法:
- 使用Dark Agouti鼠标模型模仿渐进性MS (PMS) 组织病理学.
- 给予维生素D (VD) 或标准饮食给奶后的雄性和雌性大鼠.
- 评估了髓化,微质激活,细胞亡,神经元活力,氧化性脂质,保护性多 (PP),总抗氧化能力 (TAC) 和血清神经纤维光链 (sNfL) 的水平.
主要成果:
- 与雄性相比,雌性大鼠表现出更好的抗氧化能力 (TAC,PP),更高的髓保存率,降低的微质激活率和更好的神经元存活率.
- 女人表现出延迟的疾病峰值和增加的亡细胞,而男性表现出更快的进展.
- 维生素D (VD) 补充剂减少了皮质,神经轴突和氧化损伤.
- 雄性大鼠从静脉疾病补充中获得了更明显的整体益处,这可能是由于氧化防御系统的差异.
结论:
- 在MS临床前模型中存在与性别相关的显著差异,影响疾病进展和对静脉疾病的反应.
- 维生素D (VD) 补充剂在两性中都提供神经保护性益处,在渐进性MS模型中减轻损伤.
- 雄性大鼠可能有更大的能力从VD补充中受益,可能与氧化应激管理的固有差异有关.
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