维生素D状态,VDR和TLR多态和肺结核流行病学在哈萨克斯坦
Dauren Yerezhepov1, Aidana Gabdulkayum1, Ainur Akhmetova1
1Laboratory of Genomic and Personalized Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.
Nutrients
|February 24, 2024
概括
维生素D缺乏在哈萨克斯坦非常普遍,并与结核病 (TB) 的进展有关. 在VDR和TLR8的特定基因变异,以及社会经济因素,增加肺结核风险.
科学领域:
- 遗传学和流行病学
- 公共卫生 公共卫生
- 免疫学 免疫学 免疫学
背景情况:
- 结核病 (TB) 和维生素D缺乏是哈萨克斯坦重要的公共卫生问题.
- 维生素D在免疫反应调节中起着至关重要的作用.
- 维生素D缺乏与各种健康状况有关,需要对其在结核病中的作用进行研究.
研究的目的:
- 调查哈萨克斯坦人口的维生素D状况.
- 分析与肺结核有关的VDR和TLR基因多态性.
- 检查哈萨克斯坦肺结核的流行病学.
主要方法:
- 一项涉及411名肺结核患者和686名对照者的病例控制研究.
- 血清维生素D (25-(OH) D水平通过电化学发光免疫试验测量.
- 实时PCR用于基因多态性决定;逻辑回归用于关联分析.
主要成果:
- 在结核病病例 (95%) 和对照 (43.7%) 中观察到维生素D缺乏的高患病率.
- 低BMI,失业和糖尿病等社会经济因素与结核病有显著的关联.
- VDR基因T/T多态 (rs1544410) 和TLR8基因A/A多态 (rs3764880) 与增加肺结核风险有关.
结论:
- 维生素D缺乏是常见的,并与哈萨克斯坦的结核病进展有关.
- 失业,低BMI和糖尿病是肺结核的关键危险因素.
- 在哈萨克斯坦人群中,TLR8 (rs3764880) 和VDR (rs1544410) 基因多态可能作为肺结核的生物标志物.
相关概念视频
Pulmonary Tuberculosis I
243
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
243
Pulmonary Tuberculosis IV
143
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
143
Pulmonary Tuberculosis III
326
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
326
Pulmonary Tuberculosis V
180
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
180
Pulmonary Tuberculosis II
236
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
236
Single Nucleotide Polymorphisms-SNPs
15.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.1K


