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在半孔中药物负载对无形稳定性和性能的影响

Christoffer G Bavnhøj1, Matthias M Knopp2, Korbinian Löbmann3

  • 1Pharmaceutical Development, H. Lundbeck A/S, DK-2500 Copenhagen, Denmark.

Pharmaceutics
|February 24, 2024
PubMed
概括

在干燥的条件下,半孔有效地稳定无形赛莱科西布在孔隙填充能力 (PFC) 下18个月. 在PFC上加载导致再结晶,影响溶解配置和超和.

关键词:
无形稳定性的稳定性不同扫描热量计 (DSC)溶解溶解是一种解体.装载能力 装载能力长期稳定的长期稳定性半孔性二氧化是一种中孔性二氧化溶解不良的药物 溶解不良的药物毛孔的体积,毛孔的体积.表面积面积面积面积面积面积面积面积面积面积

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