在活体中沉积高流量鼻气溶,使用呼吸增强雾化
Jeyanthan Jayakumaran1, Gerald C Smaldone1
1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
Pharmaceutics
|February 24, 2024
概括
高流量鼻腔管 (HFNC) 治疗现在可以使用新型雾化器将调节的气溶输送到肺部. 该系统允许精确定位药物输送,改善患者护理.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 医疗器械技术 医疗器械技术
- 药理动力学 药理动力学
背景情况:
- 传统的雾化器在高流量条件下在气溶输送方面存在局限性.
- 高流量鼻腔管 (HFNC) 治疗需要优化的气溶输送系统.
- 现有的设备提供不可预测的气溶输出与固定最大速率.
研究的目的:
- 用HFNC的新型雾化器测量调节的气溶输送到肺部.
- 评估i-AIRE雾化器在高空气流下提供气溶的有效性.
- 为了确定喷雾剂的输送是否可以在床边可靠地控制和定位.
主要方法:
- 9名健康的志愿者通过HFNC获得了60升/分钟的加湿空气.
- 一个呼吸增强喷气雾化器 (i-AIRE) 与HFNC系统连续使用.
- 无线电标记盐水 (99mTc DTPA) 以受控的速率 (12,20,50毫升/小时) 输注,并使用马相机测量肺部沉积量.
主要成果:
- 肺部气溶沉积率 (μg NaCl/分钟) 与输液率有很强的相关性.
- 沉积率为7.84 ± 3.2 在12毫升/小时,43.0 ± 12 在20毫升/小时,和136 ± 45在50毫升/小时.
- 沉积效率从0.441.82%不等,而边缘沉积不依赖于呼吸频率.
结论:
- 通过HFNC进行呼吸增强雾化,可靠地在高鼻气流下将气溶输送到肺部.
- 气溶输送的速度简单地通过调节输注速率来控制.
- 这项技术使得重症患者的肺部沉积的床边定位成为可能.
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