分子的物理化学特性对乳清蛋白/酸水凝的作用 病理学,微观结构和释放特征
A Delanne-Cuménal1, E Lainé1, V Hoffart2
1UMR454 MEDIS, INRAE-UCA, 63000 Clermont-Ferrand, France.
Pharmaceutics
|February 24, 2024
概括
乳清蛋白和酸盐微粒有效地封装了各种分子用于口服. 它们的特性,如粘度和弹性,影响封装效率和受控释放,特别是对离子物质.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 食品科学与技术 食品科学与技术
背景情况:
- 口服药物输送面临着分子稳定性和向释放方面的挑战.
- 乳清蛋白 (WP) 和酸盐 (ALG) 是生物相容的聚合物,具有微粒 (MP) 配方的潜力.
- 控制MP特性对于优化药物封装和释放动力学至关重要.
研究的目的:
- 在WP/ALG微粒中研究各种分子 (神叶素,蓝色德克斯,酸,胰岛素) 的封装.
- 评估封装分子对MP特征和口服药物的性能的影响.
- 探索凝类风湿学与开发的输送系统的生物制药性质之间的关系.
主要方法:
- 使用冷凝技术制备WP/ALG微粒.
- 用WP溶液对微粒进行涂层,然后再进行复杂化.
- 封装效率的表征,MP结构,胀和分子释放配置文件.
- 分析聚合物溶液的质性质及其与MP性能的相关性.
主要成果:
- 封装效率因分子特性而有显著差异 (23-100%).
- MP结构,胀和分子释放动力学受到封装物质和pH的影响.
- 涂层厚度在68至146微米之间,影响释放率 (1小时内5-80%).
- 由于聚合物相互作用而导致的凝类风湿学修饰是观察到差异的关键.
结论:
- 通过控制风湿学参数,WP/ALG微粒可以定制为口服.
- 开发的载体证明适合封装阳离子,高分子量物质.
- 通过这种配方方法,可以实现胃抵抗和受控的肠道释放.
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