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免疫检查点抑制剂和红斑性狼

Hans Vitzthum von Eckstaedt¹, Arohi Singh², Pankti Reid^3,4

¹Department of Medicine, University of Chicago Medicine, Chicago, IL 60637, USA.

Pharmaceuticals (Basel, Switzerland)

|February 24, 2024

概括

免疫检查点抑制剂 (ICI) 可以引起与免疫相关的不良事件 (irAEs),包括ICI-lupus erythematosus (ICI-LE). 大多数用ICI治疗的先前存在狼的患者没有出现狼发作,而ICI-LE病例通常是皮肤和可控的.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

免疫检查点抑制剂 (ICI) 是标准的癌症治疗方法,但可能导致与免疫相关的不良事件 (irAEs).
由ICI诱导的红性狼 (ICI-LE) 是一种罕见的irAE,在患有或没有先前存在的狼的患者中具有独特的挑战.
了解ICI-LE对于管理接受免疫治疗的癌症患者至关重要.

研究的目的:

对ICI-LE的文献进行审查,重点关注其呈现和管理.
分析先前存在狼和ICI治疗的患者的ICI治疗结果.
在案例系列中描述ICI-LE的发病率和特征.

主要方法:

对狼患者ICI-LE和ICI治疗的文献综述.
对接受ICI治疗的先前存在狼患者病例系列的分析.
ICI-LE表现的分类 (皮肤或全身) 和治疗方式.

主要成果:

大多数确诊的ICI-LE病例呈现皮肤性狼;系统性表现不太常见.
超过90%的ICI-LE病例涉及抗PD-1/PD-L1治疗.
大多数ICI狼患者的治疗是局部类固醇,氧化或口服皮质类固醇.
在病例系列中,没有先前患有狼的患者经历了狼爆发; de novo irAEs是低级的.

结论:

ICI-LE是一种罕见的irAE,主要表现为皮肤狼.
接受ICI治疗的先前患有狼的患者通常能很好地忍受治疗,狼发作最小.
ICI-LE的管理通常涉及局部或口服皮质类固醇和氧化,大多数病例在不停止ICI的情况下都可管理.

关键词:

免疫检查点抑制剂免疫检查点抑制剂免疫疗法免疫疗法美国的IRAAEAE 红血性狼是一种血红性狼.

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