基因工程微生物 (GEM) 对肠道微生物群和公共健康的潜在有害影响
Aaron Lerner1,2, Carina Benzvi1, Aristo Vojdani3
1Chaim Sheba Medical Center, The Zabludowicz Center for Autoimmune Diseases, Ramat Gan 52621, Israel.
Microorganisms
|February 24, 2024
概括
基因工程微生物 (GEMs) 可能通过横向基因转移破坏肠道微生物群,可能导致人类疾病. 目前对GEM的安全规定不足,需要专注于预防和谨慎.
科学领域:
- 微生物学 微生物学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 肠道失生症会改变微生物和宿主共同代谢物.
- 通过移动遗传元素 (MGE) 的水平基因转移 (HGT) 推动了细菌的进化.
- 引入基因工程微生物 (GEMs) 可能会破坏肠道平衡.
研究的目的:
- 为了研究GEMs的HGT在改变肠道微生物群eubiosis中的作用.
- 评估GEM对人类基因组和健康的潜在有害影响.
主要方法:
- 在PubMed/MEDLINE,EMBASE和Scielo数据库中的系统文献搜索.
- 时间框架:2000年至2023年8月.
- 使用了相关的医学主题标题 (MeSH) 术语.
主要成果:
- GEMs的水平基因交换可能会诱导各种人类疾病.
- GEMs可能会改变肠道微生物和宿主细胞的长期进化轨迹.
- 目前对GEM的全球监管监管不足以保护公共健康.
结论:
- 对GEM可行性和生物控制的不充分控制构成公共卫生风险.
- 预防策略至关重要且具有成本效益.
- 坚持"primum non nocere" (首先,不要伤害) 的原则至关重要.
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