血小板产品的细菌污染
Michael R Jacobs1, Bowen Zhou1, Aditi Tayal1
1Department of Pathology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.
Microorganisms
|February 24, 2024
概括
血小板输血中的细菌污染仍然是一个风险,尽管使用了诸如减少病原体和改进培养测试等方法. 本综述讨论了提高血小板安全性和减少输血相关感染的策略.
科学领域:
- 输血医学 输血医学
- 微生物学 微生物学
- 预防传染病 预防传染病
背景情况:
- 血小板产品的细菌污染虽然很少发生,但会造成严重的死亡和发病风险.
- 在过去的二十年中,已经实施了各种策略,以减轻血小板输血中的细菌污染.
- 现有的方法包括增强的供体查,非血小板利用,基于培养的先进测试和病原体减少技术.
研究的目的:
- 审查和讨论旨在预防血小板输血中的细菌污染的策略的演变和有效性.
- 分析不同测试方案和病原体减少方法对血小板安全性和保质期的影响.
- 突出目前的挑战和未来的方向,以确保血小板产品的细菌安全.
主要方法:
- 对血小板产品中细菌检测的既定和新兴方法的审查,包括初级和二级培养试验.
- 检查病原体减少技术,如amotosalen,以及它们在美国和欧洲的监管批准.
- 对不同测试方案的分析,包括英国的大批量延迟采样 (LVDS) 方法和美国FDA指导.
主要成果:
- 在美国 (2004年) 和英国 (2011年) 实施的初级培养试验,体积和时间的变化,旨在提高安全性.
- 自2002年以来,病原体减少技术 (amotosalen) 已在欧洲开放,并于2014年在美国获得批准.
- 最近的美国FDA指南 (2021) 建议减少病原体,LVDS变体和两步策略,将保质期从3天延长到7天.
结论:
- 尽管取得了进展,但细菌污染仍然是血小板输血安全的关键问题.
- 改进的测试方法,病原体减少和更新的监管指南的结合对于最大限度地降低风险至关重要.
- 持续的研究和实施有效的战略是必要的,以进一步提高血小板产品的安全性.
更多相关视频
12:40Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
28.7K
05:49Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
551
相关概念视频
01:18Structure and Function of Platelets
1.2K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.2K
01:22Formation of the Platelet Plug
6.2K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.2K