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探索肠道微生物群和早期青春期之间的机制相互作用:叙述性审查

Min Yue^1,2, Lei Zhang^1,2,3

¹Microbiome-X, National Institute of Health Data Science of China & Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

|February 24, 2024

概括

肠道微生物群通过荷尔蒙调节,新陈代谢和神经路径可能会影响早期青春期. 对这些肠道微生物组联系的进一步研究可能会导致这种疾病的新诊断和治疗策略.

科学领域:

内分泌学在内分泌学.
微生物学微生物学
神经科学是一个神经科学.

背景情况:

在青春期内,肠道微生物群的组成发生变化,全球范围内早发性青春期的流行率越来越高,特别是在女孩身上.
大约90%的中部早期青春期病例缺乏明确的原因,这表明潜在的环境或生物影响.
观察到肠道微生物群和早期青春期之间的联系,但确切的机制仍然不清楚.

研究的目的:

系统地审查和阐明连接肠道微生物群和早期青春期的潜在机制.
探索肠道微生物在内分泌功能,新陈代谢,肥胖和与青春期开始相关的神经调节中的作用.

主要方法:

现有文献的叙述性审查.
探索潜在的途径,包括荷尔蒙调节 (GnRH,LH,FSH),新陈代谢,肥胖链接和微生物群的神经活性化合物产生.

主要成果:

肠道微生物群可能会通过内分泌通道影响青春期的时间,通过内分泌通道调节关键的生殖激素.
微生物组对新陈代谢和肥胖的作用可能与早期青春期的发生有关.
微生物产生神经递质可能会影响中枢神经系统调节青春期.

结论:

肠道微生物群是通过多种相互关联的机制在早期青春期发展中的潜在关键参与者.
了解这些机制可以识别早期青春期的新型治疗点,如益生菌.

关键词:

儿童的健康问题内分泌干扰干扰内分泌系统我们的肠道微生物群.的新陈代谢和肥胖.微生物肠大脑轴过早的青春期过早的青春期益生菌是一种益生菌.

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