分析怀孕第三个月的阴道微生物群变化及其与早产的相关性:一项案例对照研究
Catalin Prodan-Barbulescu1,2,3, Felix Bratosin1,4,5, Roxana Folescu6
1Doctoral School, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Microorganisms
|February 24, 2024
概括
特定的阴道细菌和减少的乳酸菌与早产 (PTB) 有关. 改变的阴道微生物群和升高的免疫标志物表明PTB风险更高,表明预防的微生物点.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 免疫学 免疫学 免疫学
背景情况:
- 阴道微生物群在生殖健康中起着至关重要的作用.
- 了解其成分对于识别妊娠不良结果的风险因素至关重要,例如早产 (PTB).
- 以前的研究表明,阴道失生症和PTB之间存在联系,但具体的微生物关联需要进一步阐明.
研究的目的:
- 为了分析孕妇的阴道微生物群组成.
- 确定与早产风险增加相关的特定微生物变异.
- 研究微生物变化,局部免疫环境和PTB结果之间的关系.
主要方法:
- 涉及孕妇 (2019-2023) 的回顾性病例控制研究.
- 包括89名过早分娩的妇女和106名过期分娩的妇女.
- 分析了第三季度的阴道培养物,白细胞计数,中性粒细胞计数,阴道pH值和努根特分数.
主要成果:
- 在早产组中白细胞和中性粒细胞数量较高 (p < 0.001).
- 阴道pH值升高 (p < 0.001) 和早产婴儿中细菌性阴道炎 (p = 0.001) 的患病率增加.
- 显著的PTB与Candida spp.的关联 (OR=1.84),阴道 (Gardnerella vaginalis) (OR=2.29),人体细胞菌 (Mycoplasma hominis) (OR=1.97) 和尿素细胞菌 (Ureaplasma urealyticum) (OR=2.43) 等. 这三种菌种的发病率均为平均.
- 减少的乳杆菌种类. 与降低PTB风险相关联 (OR=0.46,p=0.001). 这种风险可能与PTB风险降低有关.
结论:
- 特定的阴道微生物群概况,包括致病细菌和改变的乳酸菌,与PTB风险有显著的关联.
- 研究结果表明,微生物因素对PTB发展至关重要.
- 针对这些微生物因素可能为PTB预防提供新的策略.
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