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通过从酒中消耗的谷物中开放环聚合合成聚乳酸,用于药物输送

Snehal R Vakati¹, Gary Vanderlaan², Matthew D Gacura²

¹Department of Bioengineering and Biomedical Engineering, Gannon University, Erie, PA 16541, USA.

|February 24, 2024

概括

这项研究将酒厂的花费谷物转化为聚乳酸 (PLA) 用于药物输送. 这种新型的PLA有效地释放了抗菌素trimethoprim,显示了先进医疗应用的潜力.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
生物技术是生物技术.

背景情况:

聚乳酸 (PLA) 是生物医学应用中广泛使用的合成聚合物支架.
PLA的局限性包括机械强度差以及降解后药物输送受损.
开发用于持续治疗释放的新型合成聚合物是一个关键的研究领域.

研究的目的:

开发一种可持续的方法,从酒厂的消耗谷物 (BSG) 中生产聚乳酸 (PLA).
为了评估BSG衍生PLA的药物排泄特性,使用trimethoprim (TMP) 作为一种模型抗菌剂.
探索BSG衍生PLA作为抗菌药物输送的药物载体的潜力.

主要方法:

从BSG通过细菌发酵生产乳酸.
乳酸酸的乳酸环聚合利用金属催化剂合成PLA.
修改的Kirby-Bauer测定用于评估PLA磁盘中的三甲 (TMP) 化.
对TMP装载的PLA与对TMP敏感的*大肠杆菌*进行评估.

主要成果:

从酒厂的消耗谷物 (BSG) 成功生产了PLA.
证明了BSG衍生的PLA释放抗微生物三甲 (TMP) 的能力.
验证了PLA作为抗大肠杆菌药物载体的有效性.

结论:

酒的花费谷物 (BSG) 可以成为生产医疗级聚乳酸 (PLA) 的可行来源.
来自BSG的PLA显示出作为一种抗菌药物输送的药物释放支架的前景.
这种方法扩大了合成聚合物在药物浸组织移植和其他医疗设备中的多功能性.

关键词:

细菌发酵细菌发酵是一种生物材料是一种生物材料.酒厂的使用过的谷物.药物排泄的合成聚合物合成聚合物乳酸盐环聚合物的聚合.金属催化剂的使用方法聚乳酸聚乳酸是什么意思持续的释放率是指持续的释放率.三甲胺是什么?三甲胺是什么?

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