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合成里瓦斯蒂格明和胰岛素组合粘膜粘合纳米颗粒用于鼻内输送

Tahereh Jamshidnejad-Tosaramandani^1,2,3, Soheila Kashanian^1,4, Isaac Karimi²

¹Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah 6714414971, Iran.

|February 24, 2024

概括

新型纳米粒子有效地将阿尔茨海默病药物,利瓦斯蒂格明和胰岛素通过鼻内途直接输送到大脑,显著提高神经退行性疾病的药物运输效率.

科学领域:

纳米技术纳米技术
神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

有效的药物输送到大脑对于治疗神经退行性疾病至关重要,如阿尔茨海默氏症 (AD).
使用纳米材料的鼻内输送为针对大脑的药物管理提供了一个有希望的策略.
乙胆酶抑制剂和胰岛素是AD管理的关键治疗药物.

研究的目的:

开发和评估一种新的组合药物输送系统,以增强里瓦斯蒂格和胰岛素的鼻内输送.
评估N,N,N-三甲基酸盐纳米颗粒 (NP) 在通过鼻腔粘膜传输治疗剂的效率.
研究这些NP在治疗阿尔茨海默病和其他神经退行性疾病方面的潜力.

主要方法:

制造N,N,N-三甲基纳米颗粒 (NP) 封装里瓦斯蒂格和胰岛素.
描述NP,包括大小,泽塔潜力和多分散性指数 (PDI).
使用NP与药物溶液相比,通过绵羊鼻腔粘膜对药物运输效率的ex vivo评估.

主要成果:

形成的NP是球形的,尺寸为187.00nm,泽塔电位为17.6mV,PDI为0.29.
与药物溶液 (分别为52%和21%) 相比,NP显著提高了里瓦斯蒂格明 (73.3%) 和胰岛素 (96.9%) 在鼻腔粘膜的运输效率.
粘粘性NP表现出卓越的药物递送能力,可同时给大脑.

结论:

新型组合粘粘性NP代表了提高鼻腔传输效率的有希望的战略.
这种药物输送系统有助于同时向大脑输送利瓦斯蒂格和胰岛素.
开发的NP有可能有效治疗阿尔茨海默病和其他神经退行性疾病.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.N,N,N-三甲基甲基酸盐的使用方法共同交付是一种共同交付.组合疗法是一种组合疗法.在这种情况下,胰岛素胰岛素.药物通过鼻内注射输送.粘粘性纳米粒子粘粘性纳米粒子里瓦斯蒂格米纳 (rivastigmine) 是一种

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