在完全接种疫苗的养老院居民和工作人员中与SARS-CoV-2感染相关的因素
Jesús Mateos-Nozal1, Mario Rodríguez-Domínguez2,3, Jesús San Román4
1Servicio de Geriatría, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, Spain.
Viruses
|February 24, 2024
概括
在接种疫苗后研究了养老院居民和工作人员对SARS-CoV-2的免疫力. 以前的感染增强了抗体反应,但Omicron变种对所有人影响均等,没有疫苗接种前因素预测结果.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 老年学是一门学科.
背景情况:
- 养老院居民面临SARS-CoV-2感染,发病率和死亡率的高风险.
- 疫苗接种工作至关重要,但需要持续评估脆弱人群的免疫力.
研究的目的:
- 评估接种疫苗的养老院居民和工作人员的幽默和细胞免疫力.
- 在这个队列中识别SARS-CoV-2感染和死亡的风险因素.
主要方法:
- 马德里养老院267名居民和302名工作人员的前性研究 (2020-2021年).
- 测量IgG,中和抗体,以及疫苗接种前后的细胞反应.
- 随访至2022年2月,以追踪感染和死亡率.
主要成果:
- 居民比工作人员更有可能先前感染COVID-19.
- 以前的感染与IgG增加和中和抗体水平相关.
- 在Omicron波中观察到的类似的SARS-CoV-2感染率在居民和工作人员中.
- 没有疫苗接种前的临床或免疫学因素预测感染或死亡率.
结论:
- 虽然先前感染增强了对疫苗接种的免疫反应,但它并没有防止Omicron变种感染.
- 免疫力在接种疫苗后同样会减弱,无论之前的感染状况如何.
- 需要进一步的研究,以了解长期护理机构的长期免疫和保护策略.
更多相关视频
相关概念视频
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K
Pneumonia V: Nursing management and Prevention
2.1K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.1K
Factors Affecting Pulmonary Ventilation
1.4K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.4K
Pneumonia II: Pathophysiology
272
The pathophysiology of pneumonia involves the following steps:
272
Pneumonia III: Complications and Assessment
215
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
215


