结核病对疾病严重程度和COVID-19患者病毒泄漏时间的影响
Wei Huang1, Ping Liu1, Bo Yan2
1Department of Tuberculosis, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Viruses
|February 24, 2024
概括
患有COVID-19的结核病患者经历了更严重的疾病和更长的病毒流失. 不到两个月的早期抗结核治疗 (ATT) 与长时间的流产有关,这表明需要集中治疗.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 公共卫生 公共卫生
背景情况:
- 越来越多的证据表明结核病 (TB) 与COVID-19疾病严重程度的增加之间存在联系.
- 了解结核病对COVID-19结果的影响,包括病毒分泌,对于患者管理至关重要.
研究的目的:
- 为了研究结核病对COVID-19疾病严重程度的影响.
- 为了确定结核病对COVID-19患者病毒分泌时间的影响.
主要方法:
- 对223名COVID-19患者 (34名结核病患者,189名没有结核病患者) 的回顾性研究.
- 收集临床数据和病毒载荷流失时间.
- 统计分析以确定与疾病严重程度和脱落持续时间相关的因素.
主要成果:
- 患有结核病的COVID-19患者显示出严重/危急疾病和死亡率更高的趋势.
- 结核病与COVID-19患者的病毒分泌持续时间明显长 (中位数为15.0 vs 11.0天).
- 结核病,老年和严重/危急的COVID-19是长期传播SARS-CoV-2的独立预测因素.
- 与较长时间治疗 (≥4个月) 相比,较短时间的抗结核治疗 (<2个月) 与较长时间的病毒分泌相关.
结论:
- 患有同时存在结核病的COVID-19患者通常会经历更严重的疾病和更差的预后.
- 结核病显著延长了COVID-19患者的病毒分泌时间.
- 接收不到两个月的抗结核治疗的COVID-19结核病患者需要加大监测,因为延长病毒流放.
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