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统计药物管理与流感敏感性之间的关联:对纵向研究的系统审查和元分析

Fan Wu¹, Congcong Wang¹, Shunran Li¹

¹School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.

|February 24, 2024

概括

使用他类药物可能会略微增加流感感染风险. 这种风险在老年人和女性中尤为明显,这表明他类药物使用者需要提高警和预防措施.

科学领域:

心血管药理学心血管药理学
传染病流行病学传染病流行病学
临床药房临床药房

背景情况:

关于他类药物治疗与流感感染易感性之间的关系,存在相互矛盾的证据.
调查这种关联的纵向研究需要系统审查和元分析以获得清晰度.

研究的目的:

为了确定他类药物使用与流感敏感性之间的关联.
综合来自多项纵向研究的数据,以提供可靠的风险评估.

主要方法:

在PubMed,Embase和Web of Science进行了系统的文献搜索,截至2023年5月21日.
使用固定和随机效应模型的元分析.
包括五项研究,包括1,472,239名他类药物使用者和1,486,881名非使用者.

主要成果:

聚合风险比 (RR) 为1.05 (95% CI:1.03-1.07) 表明与他类药物使用相关的流感感染风险增加具有统计学意义.
在调整疫苗接种情况后,这种关联仍然很重要.
亚组分析显示,60岁以上的个体 (1.06;95% CI:1.03-1.08) 和女性比例较高的小组 (1.05;95% CI:1.03-1.07) 中的RR较高.

结论:

静止剂的使用可能与流感感染的风险增加有关.
这种增加的风险在老年人群和女性中尤为明显.
对于使用他类药物的个人,建议加强健康监测和流感预防策略.

关键词:

感染风险感染风险流感流感流感流感流感类药物类药物类药物易感性易感性易感性

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