损坏的IgM记忆B细胞功能在结肠病中很常见,但结合性肺炎球菌疫苗接种会诱导强大的保护性免疫力
Olivia G Moscatelli1,2, Amy K Russell1,2, Lee M Henneken1,3
1Immunology Division, The Walter and Eliza Hall Institute, Parkville, VIC 3052, Australia.
Vaccines
|February 24, 2024
概括
结肠病患者往往有免疫缺陷,而不仅仅是缺血. 肺炎球菌合疫苗提供了更高的保护,建议所有胆固醇病患者进行常规疫苗接种.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 结肠病 (CD) 与缺症有关,损害了脏功能,增加了肺炎球菌感染风险.
- 在CD和最佳肺炎球菌疫苗接种策略中,hyposplenism的免疫后果仍然不清楚.
研究的目的:
- 为了研究CD中缺血症的免疫效应.
- 为了评估选的精度为hyposplenism.
- 在CD患者中比较肺炎球菌疫苗反应.
主要方法:
- 评估了Howell-Jolly体,红细胞和脏超声波.
- 测量IgM记忆B细胞频率和对T细胞依赖 (TD) 和T细胞独立 (TI) 刺激的反应.
- 比较了对结合 (TD) 和多糖 (TI) 疫苗的ELISA和opsonofagocytic测定反应.
主要成果:
- 在接受治疗的CD中,缺血症是罕见的 (5.1%),但功能性B细胞缺陷很常见 (28-61%),目前的测试无法检测到.
- 结合性肺炎球菌疫苗接种诱导了对关键血清型的优越和持续的保护.
- 在CD患者的免疫缺陷不仅仅是通过hyposplenism解释.
结论:
- 目前临床测试的hyposplenism是不充分的CD患者.
- 建议所有CD患者进行常规的肺炎球菌疫苗接种,最好是用联合疫苗接种.
- 疫苗接种策略应针对功能性B细胞缺陷,而不仅仅是对hyposplenism查.
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