自身免疫运动障碍使免疫检查点抑制剂治疗复杂化
Alessandro Dinoto1, Milena Trentinaglia1, Sara Carta1
1Neurology Unit, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
免疫检查点抑制剂 (ICI) 很少会导致自身免疫运动障碍 (MD). 及时识别和治疗对于管理这种罕见的癌症免疫治疗并发症至关重要.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 免疫检查点抑制剂 (ICI) 用于癌症治疗.
- ICI可以导致自身免疫神经疾病,特别是运动障碍 (MD).
研究的目的:
- 从ICI治疗中产生的免疫相关不良事件 (irAEs) 产生的运动障碍 (MDs) 的特征.
主要方法:
- 进行了系统的文献审查.
- 包括案例报告和系列详细介绍MD作为ICI的irAEs.
主要成果:
- 分析了26篇文章中的28名患者.
- MDs是罕见的,呈现异质,经常与其他irAEs.
- 大脑成像通常不显示,尽管CSF可能表明炎症;自身抗体很常见.
- 类固醇和ICI戒断通常会改善症状,但可能会出现复发.
结论:
- 运动障碍是ICI的一个罕见但显著的并发症.
- 早期识别和适当的管理对于患者的结果至关重要.
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