在可变机械负荷范式下,增材制造的PLGA的降解动力学的表征
Anna N Smith1, Joseph B Ulsh1, Richa Gupta1
1McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Journal of the mechanical behavior of biomedical materials
|February 24, 2024
概括
可生物降解的聚乳糖合糖酸 (PLGA) 植入物的受控降解加速了愈合. 增材制造对PLGA脚手架性能产生影响,在8至16周之间观察到显著的降解,有利于骨修复.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科工程 整形外科工程
- 降解动力学的降解动力学
背景情况:
- 可生物降解的聚乳糖合糖酸 (PLGA) 植入物提供了通过可控降解加速骨折愈合的潜力.
- 增材制造可以调整PLGA脚手架的机械性能,但其对降解的影响尚不清楚.
研究的目的:
- 使用体外和体外模型研究添加制造的PLGA试验券的降解动力学.
- 确定灌装密度和格子架构对PLGA植入物的机械性能和降解的影响.
主要方法:
- 使用增材制造制造多孔和固体PLGA (85:15) 试验券的制造.
- 在体外化在血清和体内皮下植入在老鼠体内,长达16周.
- 机械测试 (张力,压缩,扭曲,曲) 以评估刚性和最终的力.
主要成果:
- 灌装密度显著影响了最初的机械性能,而格子架构的影响最小.
- 在8周观察到中度降解,所有标本在16周后机械性能显著下降.
- 3D打印PLGA植入物的实质性降解发生在8至16周之间.
结论:
- 增材制造允许通过灌装密度控制PLGA植入物的初始机械性能.
- 观察到的3D打印PLGA植入物的降解概况表明,对骨折修复应用有潜在的好处.
- 需要进一步的研究来阐明植入物设计,多孔性和生物降解之间的复杂相互作用.
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