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Updated: Jul 2, 2025

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产前暴露于per-和多基基物质和婴儿人类学之间的关联:前性队列研究

Jincan Li¹, Xiujuan Su², Yan Zhou³

¹Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Department of Public Health, Fudan University, Shanghai, 200237, China.

International journal of hygiene and environmental health

|February 24, 2024

概括

产前暴露在per-和多基基物质 (PFAS) 中会影响婴儿的生长. 某些PFAS如PFDoA和PFNA增加了婴儿大小,而PFOA降低了男性的婴儿大小,影响了整体生长轨迹.

科学领域:

环境健康环境健康
儿科内分泌学儿科内分泌学
毒理学毒理学毒理学

背景情况:

和多基基物质 (PFAS) 是与内分泌干扰相关的合成化学物质.
以前的研究表明,暴露于PFAS会影响后代的身体成长.
产前PFAS暴露对婴儿人类学的影响需要进一步调查.

研究的目的:

调查产前 PFAS 暴露对婴儿反复进行的人类测量测量的影响.
分析特定的PFAS化合物与婴儿生长指标之间的关联.
评估PFAS混合物对婴儿发育的综合影响.

主要方法:

在孕妇中测量了血清PFAS水平 (n=964).
婴儿的人类指标 (体重与年龄,体重与长度,头周长与年龄,手臂周长与年龄,皮) 在出生,6个月和12个月被评估.
使用多变量线性回归,概括估计方程 (GEE) 和贝叶斯内核机器回归 (BKMR).

主要成果:

perfluorododecanoic 酸 (PFDoA) 和 perfluorononanoic 酸 (PFNA) 与婴儿体重和手臂周长增加有关.
PFAS混合物显示体重与年龄和体重与身长的比例增加,特别是在女性身上.
perfluorooctanoic 酸 (PFOA) 与男性体重,头部和手臂周长的减少有关.

结论:

产前暴露于PFNA和PFDoA与增强的婴儿人类学有关,特别是在女性中.
产前PFOA暴露与男性人体测量指标的减少有关.
产前暴露于PFAS可能会破坏婴儿正常生长轨迹.

关键词:

婴儿时期的婴儿时期和多醇基物质是多和多的.产后生长产后生长产后生长产前暴露在产前暴露.展望性研究是一项前性研究.

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