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Updated: Jul 2, 2025

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

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新设计的塔克林衍生胆酶抑制剂的多目标潜力:合成,计算和药理学研究

Ivana I Jevtić1, Relja V Suručić2, Gordana Tovilović-Kovačević3

  • 1University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Njegoševa 12, 11000 Belgrade, Serbia.

Bioorganic & medicinal chemistry
|February 24, 2024
PubMed
概括

研究人员开发了用于阿尔茨海默病 (AD) 治疗的新型塔克林衍生物. 这些化合物表现出强烈的胆酶抑制,抗氧化和神经保护作用,具有药物开发潜力.

关键词:
ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME ADME阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.胆化酶是一种胆酶.细胞毒性 细胞毒性分子对接是分子对接.分子动力学分子动力学神经保护是一种神经保护.皮佩里丁-4-碳胺胺塔克里因是指一个神经元.

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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
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