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唾液腺癌:朝着更个性化的方法

Layal Rached¹, Khalil Saleh¹, Odile Casiraghi²

¹Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, Villejuif 94800, France.

Cancer treatment reviews

|February 24, 2024

概括

唾液腺癌 (SGCs) 是一种罕见的癌症,具有多种亚型. 识别诸如雄激素受体,HER-2和TRK状态等遗传变异指导有针对性的疗法和临床试验,以获得更好的治疗结果.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
病理学病理学病理学

背景情况:

唾液腺癌 (SGC) 很少见,占所有癌症的不到1%,有21种不同的组织学亚型.
这种罕见性对临床试验构成挑战,目前对复发性/转移性疾病的治疗方法有限,化疗显示出令人失望的结果.

研究的目的:

审查SGCs中常见的遗传改变.
突出可操作的突变及其治疗影响.
讨论目前和新兴的针对性疗法和SGCs的临床试验.

主要方法:

关于SGCs的当前文献的审查.
基因变异及其诊断/治疗相关性的分析.
免疫组织化学和下一代测序发现的总结.

主要成果:

SGC亚型表现出多样化的遗传变化,其中一些对诊断至关重要,而另一些则用于向治疗.
指南建议在特定的SGC类型中测试雄激素受体,HER-2和TRK状态.
下一代测序揭示了更多可操作的突变 (例如,NOTCH,PI3K,BRAF,MYB,EGFR).

结论:

在SGCs个性化治疗策略中,分子分析至关重要.
基于特定遗传变化的向治疗为患者提供了新的希望.
目前正在进行的研究和临床试验正在扩大SGCs的治疗选择.

关键词:

雄激素受体的受体是什么这就是BRAF.在HER2中,HER2是HER2.没有任何东西.俄罗斯国家广播电视台 (NTRK)唾液腺癌是一种唾液腺癌.

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