相关实验视频

Updated: Jul 2, 2025

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

Published on: July 17, 2018

长期储存脂肪组织的特定变化在治疗壮成长后的脂肪组织

Camilla M Falch^1,2,3, Kristin Godang¹, Tove Lekva³

¹Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital (OUS), PO Box 4950 - Nydalen, 0424 Oslo, Norway.

European journal of endocrinology

|February 24, 2024

概括

在长期内,壮症治疗在特定的储存点增加脂肪组织 (AT) 质量,并且在两性之间存在差异. 葡萄糖代谢迅速改善,并在疾病控制后保持稳定.

科学领域:

内分泌学在内分泌学.
代谢障碍代谢障碍代谢障碍
身体组成分析分析.

背景情况:

活跃的壮症与脂肪组织 (AT) 质量减少有关.
短期研究表明,在治疗后,AT仓库的特定收益.
长期持久性和AT变化的性别依赖性仍然不清楚.

研究的目的:

在壮病治疗后,特征地描述AT的特定变化.
确定影响这些AT变化的因素.
评估壮症治疗对身体组成的长期影响.

主要方法:

双能X射线吸收计 (DXA) 测量了内脏 (VAT),皮下 (SAT) 和总 (TAT) 脂肪组织,以及在诊断时,短期和长期随访时的安卓/肌骨比例 (A/G比率).
记录了临床和生化数据,包括GH,IGF-1,葡萄糖,HbA1c,淋巴状况和糖尿病.
混合模型分析评估了基于性别,糖尿病,淋巴腺和缓解状态的时间AT变化.

主要成果:

尽管BMI稳定,但增值税和A/G比率长期上升;SAT短期上升并停滞.
男性的增值税和A/G比率更高,A/G比率的增加比女性更大.
短期观察到改善的葡萄糖代谢 (降低葡萄糖和HbA1c),并持续长期.

结论:

巨症的治疗会诱导AT质量在体位和性别特定的增加,持续长期.
葡萄糖代谢在疾病控制后显示出快速和持续的改善.
在AT储存的变化与疾病活动的减少相关,独立于缓解状态.

关键词:

在糖尿病中,糖尿病是血糖类的.双能量X射线吸收度学缓解缓解是一种缓解.皮下脂肪组织的脂肪组织.通过状垂体手术的手术.内脏脂肪组织的脂肪组织.

更多相关视频

Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Published on: June 9, 2023

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

相关概念视频

Hypodermis

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

Insulin: Dosing Regimen and Adverse Effects

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...