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Updated: Jul 2, 2025

Cycloheximide Chase Analysis of Protein Degradation in Saccharomyces cerevisiae
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在26S蛋白酶和Cdc48 ATPase之间的双向基质穿促进了蛋白质降解

Hao Li1, Zhejian Ji1, Joao A Paulo2

  • 1Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

Molecular cell
|February 24, 2024
PubMed
概括

26S蛋白酶分解了大多数真核蛋白质. 好折叠的蛋白质需要Cdc48 ATPase (p97/VCP) 展开,涉及最小的蛋白质酶系统,Cdc48-UN,Rad23,Ubx5和Shp1,使基质降解成为可能.

关键词:
在AAA ATPase中使用.Cdc48 在线播放欧洲议会 (ERAD) 委员会.在P97中,P97是P97的代码.蛋白质酶体蛋白质组是什么蛋白质降解 蛋白质降解蛋白质展开的展开过程穿的因素是穿因素.在任何地方都是无处不在的.

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