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Updated: Jul 2, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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了解TDP-43功能中的与年龄相关的病理变化以及对RNA拼接和信号在健康和疾病中的影响

Flora Cheng1, Tyler Chapman1, Selina Zhang1

  • 1Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, Australia.

Ageing research reviews
|February 24, 2024
PubMed
概括

TAR DNA结合蛋白-43 (TDP-43) 功能障碍改变了RNA剪接,影响了衰老和神经退行性疾病中的基因表达. 本综述强调了TDP-43功能障碍中的新型非典型RNA作为潜在的治疗点和生物标志物.

关键词:
这是循环RNARNA.一个神秘的外型子.这是一个微型RNA.神经退行发生神经退行.拼接一些osome.在TDP-43中使用.

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