在初级全膝关节整形术后,黑色素能改善睡眠吗? 一个随机的,双盲的,安慰剂控制的试验
Muhammad A Haider1, Kyle W Lawrence1, Thomas Christensen1
1Department of Orthopedic Surgery, NYU Langone Health, New York, New York.
The Journal of arthroplasty
|February 24, 2024
概括
在全膝关节整形术 (TKA) 后的最初几天,黑素可能会改善睡眠时间,但在术后的第三天,益处会减少. 这种补充剂对于TKA患者具有早期睡眠障碍是安全的.
科学领域:
- 整形外科 整形外科 整形外科
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在全膝关节整形术 (TKA) 后,睡眠障碍很常见,可能会影响患者的满意度和恢复.
- 没有确立的术后方案来管理TKA后的睡眠问题.
研究的目的:
- 研究黑激素在促进健康睡眠和减少TKA后急性康复阶段患者睡眠障碍的疗效.
主要方法:
- 一项随机对照试验,涉及138名接受选择性TKA的患者.
- 参与者在术后14天内每晚接受5毫克黑激素或安慰剂.
- 睡眠日记,疼痛视觉模拟量表和验证的问卷 (PROMIS睡眠障碍,爱普沃思睡眠量表) 用于数据收集.
主要成果:
- 黑色素组在术后第二天和第三天的睡眠时间增加的趋势,在前三天的平均值,虽然不是统计学上显著.
- 在手术后的黑激素和安慰剂组之间,没有发现睡眠障碍得分或夜间唤醒的显著差异.
- 两组都报告了与基线相比睡眠障碍增加的比例相似.
结论:
- 在TKA后的早期术后期内,黑色素可能对睡眠时间产生适度的益处,在术后的第三天后,效果会减弱.
- 虽然严重的睡眠障碍是TKA后常见的,但黑激素可能会提供轻微的减弱作用.
- 黑色素是TKA患者经历急性术后睡眠障碍的安全选择.
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