阻塞性睡眠呼吸暂停与SARS-CoV-2感染的急性后续症状的关联
Stuart F Quan1, Matthew D Weaver1, Mark É Czeisler2
1Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Mass; Division of Sleep Medicine.
The American journal of medicine
|February 24, 2024
概括
阻塞性睡眠呼吸暂停会增加患有SARS-CoV-2感染 (PASC) 症状的急性后续症状的风险. 阻塞性睡眠呼吸暂停的治疗可能会降低这种风险,这表明它在PASC研究中的重要性.
科学领域:
- 睡眠医学 睡眠医学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与COVID-19有关.
- 目前尚不清楚OSA作为SARS-CoV-2感染 (PASC) 后急性继发症的危险因素的作用.
研究的目的:
- 调查阻塞性睡眠呼吸暂停和PASC在美国成年人群中的发展之间的关联.
主要方法:
- 对24803名美国成年人进行了横截面调查.
- 使用后勤回归模型来分析OSA和PASC症状之间的关联.
- 弹性净回归确定了整体PASC定义的关键预测因素.
主要成果:
- 阻塞性睡眠呼吸暂停与所有评估的PASC相关的身体和心理健康症状有关.
- 患有OSA的人患PASC的几率明显高于OSA的人 (ORs在1.934-2.071).
- 阻塞性睡眠呼吸暂停的治疗减轻了发展PASC的风险.
结论:
- 阻塞性睡眠呼吸暂停与PASC症状的风险增加和全球PASC诊断有关.
- 治疗阻塞性睡眠呼吸暂停可以降低PASC的风险.
- 识别患有三种或更多PASC症状的患者可能有助于病例识别和未来的研究.
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