支气管病和喘:来自欧洲支气管病登记处 (EMBARC) 的数据
Eva Polverino1, Katerina Dimakou2, Letizia Traversi1
1Pneumology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, CIBERES, Barcelona, Spain.
The Journal of allergy and clinical immunology
|February 24, 2024
概括
喘在支气管切除症患者中很常见,增加了恶化的风险. 吸入性皮质类固醇 (ICS) 在患有喘 (BE + A) 的支气管切除症患者的使用减少了死亡率和住院治疗,并观察到意外的整体死亡率降低.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 临床流行病学临床流行病学
背景情况:
- 喘经常被诊断为患有支气管切除症的个体.
- 了解喘支气管病的独特临床特征和结果 (BE+A) 对于患者的管理至关重要.
研究的目的:
- 为了比较 bronchiectasis 和喘 (BE+A) 患者的临床表型和结果,与仅有支气管支气管的患者进行比较.
- 调查吸入性皮质类固醇 (ICS) 使用对BE+A队列结果的影响.
主要方法:
- 一个前性的泛欧洲观察注册 (欧洲多中心支气管支气管检查和研究合作) 包括16963名成年患者,CT确认支气管支气管.
- 喘诊断是调查人员报告的. 统计分析包括恶化频率的负二项式回归和生存的Cox比例危险回归.
主要成果:
- 31.0%的患者有BE+A. BE+A组年轻,更常见的是女性,从未吸烟,BMI,鼻炎,鼻,eosinophilia和Aspergillus敏感性更高.
- BE+A患者具有相似的微生物学特征,但疾病严重程度较低. 他们面临着恶化风险的增加,但在使用ICS时,死亡率和住院治疗减少.
- 意想不到的是,BE+A与显著降低全因死亡率有关.
结论:
- 伴有喘的支气管切除 (BE+A) 是普遍存在的,并且与更高的恶化率有关.
- 吸入性皮质类固醇 (ICS) 治疗显示出保护作用,减少了BE+A患者的死亡率和住院治疗.
- 在BE+A患者中发现较低的死亡率需要进一步调查.
相关概念视频
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
COPD: Management Using Bronchodilators and Corticosteroids
206
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
206
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Asthma: Pathogenesis and Management
398
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
398


