阴性脂质体配方用于口服输送硫CD,一种潜在的抗微生物治疗方法
Camila Viera Herrera1, Paula M O'Connor2, Poonam Ratrey1
1Department of Chemical Sciences, Bernal Institute, University of Limerick, Ireland.
International journal of pharmaceutics
|February 24, 2024
概括
图里辛CD是一种窄谱抗微生物药物,对Clostridioides difficile有潜力. 将其封装在离子脂质体中可以提高其稳定性和生物可用性,以便在结肠中进行向输送.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 药物运输 药物运输 药物运输
背景情况:
- 图里辛CD是一种来自Bacillus thuringiensis的两抗菌剂,具有针对Clostridioides difficile的窄谱活性.
- 类抗生素在体内常常面临稳定性,溶解性和透性的挑战.
- 硬肠杆菌感染 (CDI) 是结肠传染病的重要原因之一.
研究的目的:
- 为了研究硫素CD的生物活性和生物可用性.
- 开发一种配方,有效地通过胃肠道 (GIT) 输送素CD,在结肠中发挥局部作用.
主要方法:
- 在模拟的胃和肠液中评估了硫素CD活性,稳定性和溶解性.
- 在阳离子脂质体中封装的图里辛CD.
- 评估了脂质体配方的活性,稳定性和毒性.
主要成果:
- 图里辛CD需要这两种来起作用,并且被蛋白酶降解,不稳定,在胃液中溶解不良.
- 脂质体封装增加了硫素CD活性,溶解性和GIT液体中的稳定性.
- 该配方在暴露于素后保持活性,显示长期稳定性,对肠道细胞无毒.
结论:
- 基于离子脂的纳米配方是一种有前途的策略,用于局部口服输送硫CD.
- 脂质体封装克服了图里辛CD的稳定性和生物可用性限制.
- 这种方法可以为结肠中Clostridioides difficile感染提供有效的治疗方法.
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