精确瘤学,个性化医学和分子瘤板的演变
Yu Fujiwara1, Shumei Kato2, Razelle Kurzrock3
1Department of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA.
Surgical oncology clinics of North America
|February 24, 2024
概括
分子瘤板 (MTBs) 通过将向疗法与遗传改变相匹配来指导个性化癌症医学. 证据支持它们的可行性和生存益处,即使在外科手术期间.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 个性化医疗是个性化的医疗.
背景情况:
- 选择最佳的癌症治疗需要将分子变化与向治疗相匹配.
- 分子瘤板 (MTB) 对于多学科个性化药物供应至关重要.
- MTBs的作用正在扩大,超越了晚期癌症,进入外科手术环境.
研究的目的:
- 突出分子瘤板 (MTB) 在个性化癌症治疗中的重要作用.
- 讨论将MTB整合到针对性治疗和免疫治疗的外科环境中.
- 审查关于MTB引导匹配疗法的可行性和生存益处的累积证据.
主要方法:
- 关于分子瘤板和个性化癌症治疗的当前文献的综述.
- 分析MTB决策中的多学科方法.
- 检查证据支持在各种癌症设置匹配治疗.
主要成果:
- 多基因基因测试有助于根据特定的基因变异选择有效的分子向疗法.
- 以MTB为指导的个性化医疗越来越多地应用于外科手术期间.
- 证据表明,接受MTB推的匹配疗法的患者的可行性和改善的生存结果.
结论:
- 分子瘤板是现代瘤学的组成部分,使精准医学成为可能.
- 参与MTB的范围正在扩大,影响了外科手术期间的癌症护理.
- 由MTBs指导的匹配疗法显示出显著的临床益处和生存优势.
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