新辅助和辅助环境中的向疗法,生物制剂和免疫疗法:外科手术期间的风险
Daisuke Nishizaki1, Ramez N Eskander2
1Division of Hematology and Oncology, Department of Medicine, Center for Personalized Cancer Therapy, University of California San Diego, Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 92037, USA.
Surgical oncology clinics of North America
|February 24, 2024
概括
分子向疗法和免疫检查点抑制剂 (ICI) 在新辅助癌症治疗中提供了显著的好处. 外科瘤学家必须了解与这些革命性疗法相关的潜在药物外科相互作用和并发症.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 药理学 药理学 是一个学科.
背景情况:
- 癌症治疗已经通过分子向疗法和免疫检查点抑制剂 (ICI) 取得了进展.
- 新辅助疗法,特别是ICI,在黑色素瘤和非小细胞肺癌等固体瘤中显示出临床益处.
- 这些新型疗法可能会导致与治疗相关的不良事件.
研究的目的:
- 告知外科瘤学家关于新辅助分子向疗法和ICI的术后影响.
- 突出潜在的药物和手术相互作用以及在手术前的并发症.
- 引导新型癌症治疗药物的安全整合到外科实践中.
主要方法:
- 对新辅助疗法及其手术影响的当前文献的综述.
- 对针对性疗法和ICI特有的药物手术相互作用的分析.
- 识别与外科瘤学相关的常见和关键不良事件.
主要成果:
- 新辅助疗法可以改变手术场景,影响伤口愈合和免疫反应.
- 特定的分子向剂和ICI具有独特的外科外科考虑.
- 了解这些相互作用是管理手术并发症的关键.
结论:
- 外科瘤学家需要专门的知识来管理接受新辅助分子向疗法和ICI的患者.
- 药物和手术相互作用的积极识别和管理对于最佳的患者结果至关重要.
- 这种理解至关重要,因为新辅助疗法的使用扩展到各种固体瘤.
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