通过外源电场诱导的神经阶段前行
Miles Wischnewski1, Harry Tran2, Zhihe Zhao2
1Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA. mwischne@umn.edu.
Nature communications
|February 24, 2024
概括
阶段前行,神经编码机制,与大脑节奏有因果关系. 人类和灵长类动物的交流电刺激证明了其全球新皮质作用和NMDA受体驱动的可塑性.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 神经编码 神经编码
背景情况:
- 阶段前行,神经尖端相对于局部场势 (LFP) 的转移,与神经编码和神经可塑性有关.
- 现有的研究表明,大脑各区域的阶段前行和行为之间存在相关性.
- 对于阶段前置的因果证据和潜在的神经可塑性机制在很大程度上仍未被探索.
研究的目的:
- 为了确定LFP动态和相位前行之间的因果关系.
- 为了研究神经可塑性机制驱动相位前行.
- 探索用于治疗神经调节的交流电刺激的潜力.
主要方法:
- 在人类,非人类灵长类动物和计算模型中使用交流电 (AC) 刺激来调节LFPs.
- 在人类中测量皮质脊髓刺激性转移的测量.
- 在灵长类动物中记录神经活动和诱导相位前行.
- 神经回路的多尺度建模以阐明可塑性机制.
主要成果:
- 对人类运动皮层振荡的持续交流刺激诱导了最大皮层脊髓刺激的~90°相位转移.
- 外源性AC刺激成功诱导了非人类灵长类动物中约30%的带入神经元的相位前行.
- 计算模型表明,AC刺激诱导的相序是由NMDA受体介导的突触可塑性驱动的.
结论:
- 这项研究提供了作为全球新皮层过程的相前行机制和因果关系证据.
- 交流刺激可以诱导相序和随后的突触可塑性.
- 这些发现对于开发新的治疗神经调节策略至关重要.
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