三维染色体组织对真菌植物病原体基因组进化的影响
David E Torres1,2, H Martin Kramer1, Vittorio Tracanna3
1Laboratory of Phytopathology, Wageningen University and Research, Droevendaalsesteeg 1, 6708 PB, Wageningen, The Netherlands.
Nature communications
|February 24, 2024
概括
这项研究揭示了Verticillium dahliae的3D基因组组织,显示了不同的拓关联域 (TAD),并突出了基因组结构如何影响病原体进化和宿主相互作用.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 分子生物学分子生物学
背景情况:
- 细胞基因组的空间组织影响生物功能和基因组进化.
- 植物病原体Verticillium dahliae具有与宿主感染相关的适应性基因组区域 (AGR).
- 3D基因组结构对基因组进化的影响尚不清楚.
研究的目的:
- 为了研究植物病原体Verticillium dahliae.e.的3D基因组组织.
- 了解基因组结构,自适应基因组区域 (AGR) 和进化特征之间的关系.
- 为了探索维尔提西物种中保存的3D基因组组织模式.
主要方法:
- 在3D基因组测序和分析Verticillium dahliae.
- 拓关联域 (TAD) 的识别和表征.
- 在相关物种中对基因组组织的比较分析.
主要成果:
- 短距离相互作用在V. dahliae中形成明显的TAD,具有明显的边界影响基因表达和变异.
- 与核心基因组相比,TAD绝缘在AGR中减少.
- 双相长距离相互作用富含AGR,并与细分重复相关.
- 观察到的3D基因组组织模式在其他Verticillium物种中得到保留.
结论:
- 在V. dahliae中,3D基因组组织与进化保存特征有关.
- 基因组架构,特别是在AGR中,在病原体的适应和进化中发挥着作用.
- 这项研究提供了对基因组结构和Verticillium属的进化轨迹之间的相互作用的见解.
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