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José María Martínez-de-la-Casa¹, María Teresa Marcos-Parra², Elena Millá-Griñó³

¹Ophthalmology Unit, Department of Ophthalmology and ORL, Faculty of Medicine, Hospital Clinico San-Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San-Carlos (IdISSC), Universidad Complutense de Madrid, Calle del Prof Martín Lagos, s/n, 28040, Madrid, Spain. jmmartinezcasa@gmail.com.

Scientific reports

|February 24, 2024

概括

在XEN63支架有效降低眼内压力 (IOP) 和减少药物需求在初级开角青光眼 (POAG) 患者. 独立的XEN63和与化过程结合的XEN63都显示出可比的安全性和有效性.

科学领域:

眼科医生眼科眼科
玻璃眼的手术玻璃眼的手术
医疗器械医疗器械

背景情况:

主要开角青光眼 (POAG) 是全球不可逆转失明的主要原因.
有效的IOP管理对于预防光眼神经损伤至关重要.
目前的治疗方法可能无法达到目标IOP或需要多种药物.

研究的目的:

评估XEN63支架在患有医学上不受控制的POAG.患者中的有效性和安全性.
为了比较XEN63支架植入的结果作为一个独立的程序,而不是与化结合的结果.

主要方法:

80名患有医学上不受控制的POAG的80名患者的80只眼睛被纳入.
患者接受了XEN63独立植入 (43只眼睛) 或XEN63+法化 (37只眼睛).
手术成功被定义为≥20%的内血压降低和绝对内血压在6-18mmHg之间,有或没有药物.

主要成果:

总体成功率为68.8%. 独立的XEN63获得了69.8%的成功率,而XEN63+法化获得了67.6%的成功率 (p=0.6133).
平均内血压从基线显著下降在两组 (p<0.0001),没有显著差异.
在总样本中,眼部低血压药物的平均数量从2.3下降到0.3.

结论:

单独使用XEN63支架或与发泡化相结合,有效降低POAG患者的内脏压力和减少药物依赖.
虽然观察到过渡性低血压,但它仅在一个病例中具有临床意义.
植入XEN63提供了一个可行的手术选择,用于管理医学上不受控制的POAG.

关键词:

球形成型装置球形成型装置眼光障碍症是什么眼光障碍症是什么 IOPOP IOPOP IOPOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP 这就是MIGS.主要的开放角光眼.在次周期性 MIGS 中.

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