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Updated: May 11, 2026

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在COVID-19患者中使用sublingual形式的squalene:一个随机临床试验

Mahmoud Ebrahimi¹, Nafiseh Farhadian², Sara Saffar Soflaei³

¹Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Scientific reports

|February 24, 2024

概括

从南瓜种子油中提取的舌下素显著降低了COVID-19患者的死亡率和再住院率. 这种微乳液形式显示出作为对严重COVID-19结果的有效治疗的承诺.

科学领域:

生物化学和药理学生物化学和药理学
传染性疾病传染性疾病
临床医学临床医学

背景情况:

COVID-19对全球健康构成重大威胁,需要新的治疗干预措施.
烯是一种天然化合物,已显示出潜在的生物活性.
开发有效的治疗剂输送系统对于患者的治疗结果至关重要.

研究的目的:

调查语言下方方烯微乳液在降低COVID-19患者死亡率方面的疗效.
评估语言下素对预防COVID-19相关的再住院治疗的影响.
评估一种用于取和配制烯的新方法,用于舌下注射.

主要方法:

一项随机临床试验,涉及602名符合条件的COVID-19患者 (301例,301例对照).
该病例组接受了标准治疗加上5天的语言下方 squalene 微乳液.
患者在出院后被监测了30天,以记录死亡率和再住院事件.

主要成果:

语言下方 squalene显著降低了COVID-19患者的死亡率 (94.7%的存活率与对照组的81.4%相比,p < 0.001).
斯奎林治疗大大降低了由于COVID-19而导致的再住院率 (19.3%与对照组的46.8%相比,p < 0.001).
微乳液配方促进了素的有效的舌下输送.

结论:

微乳液形式的语言下方方是一种有效的COVID-19治疗剂.
这种治疗显著降低了住院COVID-19患者的死亡率和再住院率.
新的烯提取和配方方法使其能够在临床上应用.

关键词:

在 COVID-19 疫情中,早期治疗早期治疗死亡率死亡率死亡率重新住院治疗的情况这就是SARS-COV-2病毒.斯克瓦林是一种质.

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