儿童肠道微生物组合 患有糖原储存的I型患者肠道微生物组合
Sabire Gokalp1, Ener Cagri Dinleyici2, Cansu Muluk3
1Gazi University Faculty of Medicine, Department of Pediatric Nutrition and Metabolism, Ankara, Turkey. sabire32@hotmail.com.
European journal of clinical nutrition
|February 24, 2024
概括
患有糖原储存疾病I (GSD I) 的儿童表现出显著的肠道微生物群变化,包括与饮食有关的减少Faecalibacterium prausnitzii和增加Akkermansia muciniphila. 这些变化可能会影响疾病管理.
科学领域:
- 微生物学 微生物学
- 人体生理学 人体生理学
- 儿科胃肠病学 儿科胃肠病学
背景情况:
- 糖原储存疾病I (GSD I) 的饮食管理涉及频繁食,高复杂碳水化合物 (未煮熟的玉米),糖限制和较低的脂质.
- 关于GSD I饮食方案如何影响肠道pH值和微生物群组成的数据有限.
研究的目的:
- 在接受饮食治疗的GSD I患者中调查肠道微生物组合.
- 确定与GSD I及其管理相关的特定微生物转移.
主要方法:
- 使用16S rRNA基因测序来分析肠道微生物群.
- 研究包括12名接受饮食治疗的GSD I患者和11名健康儿童作为对照.
主要成果:
- 在GSD I患者和对照人群之间观察到β-多样性的显著差异.
- GSD I 患者表现出较低的 Firmicutes 和更高的 Actinobacteria 丰度.
- 在GSD I中占主导地位的属是Akkermansia,Pseudoalteromonas,Uruburella和Castellaniella,与对照中的Faecalibacterium,Bacteroides,Gemmiger和Parabacteroides形成鲜明对比. 在物种层面上,Faecalibacterium prausnitzii减少,而Akkermansia muciniphila在GSD I患者中增加.
结论:
- 在未煮熟的玉米粉饮食中,GSD I患者表现出实质性的肠道微生物群变化,包括减少F. prausnitzii和增加A. muciniphila.
- 这些微生物变化可能与GSD I本身或饮食干预有关.
- 在GSD I中肠道失调可能会使疾病的过程和管理复杂化.
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