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尿中丁素与自我报告的吸烟以及慢性病风险相比

Setor K Kunutsor¹, Richard S Dey², Daan J Touw³

¹Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

|February 25, 2024

概括

尿中的丁氨酸是慢性病 (CKD) 风险的更可靠指标,而不是自我报告的吸烟. 这项研究发现,与自我报告不同的是,可提宁评估的吸烟独立于白分泌.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
流行病学流行病学
生物标志物生物标志物

背景情况:

吸烟是慢性病 (CKD) 的已知危险因素之一.
以前的证据主要使用自我报告的吸烟状态,这可能是不准确的.
需要对吸烟进行客观评估,以澄清其与CKD的关联.

研究的目的:

为了比较自我报告的吸烟状态与CKD风险的关联.
为了比较尿中丁胺水平与CKD风险的相关性.
确定不同吸烟评估方法的可靠性,以预测CKD.

主要方法:

前性队列研究 (PREVEND) 涉及4333名没有基线CKD的参与者.
吸烟状况通过自我报告和尿液中胆固醇蛋白进行评估.
参与者分为从未吸烟者,前吸烟者,轻吸烟者和重吸烟者.
危险比率 (HRs) 计算为CKD发病率,调整为风险因素和尿路白蛋白分泌 (UAE).

主要成果:

自我报告的当前吸烟显示与CKD风险增加有关,这取决于阿联.
尿中丁胺评估的当前吸烟与增加CKD风险的相关性.
素评估的吸烟与CKD风险之间的关联独立于阿联.

结论:

自我报告的吸烟状况与CKD的联系受尿蛋白分泌的影响.
尿中丁氨酸提供了更强大,更独立的CKD风险指标.
与自我报告相比,生物标志物评估 (尿中丁胺) 提供了更好的CKD发病率风险预测.

关键词:

慢性脏疾病慢性脏疾病队列研究是一项队列研究.科提宁是一种可替尼的成分.风险因素的风险因素是什么吸烟是为了吸烟.

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