在Drosophila中组织一个传递飞行电机状态的上升电路
Han S J Cheong1, Kaitlyn N Boone2, Marryn M Bennett3
1Department of Biology, West Virginia University, Morgantown, WV 26505, USA; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA; Zuckerman Institute, Columbia University, New York, NY 10027, USA.
Current biology : CB
|February 25, 2024
概括
动物通过附带放电回路 (CDC) 来区分自我产生的感觉与外部的感觉. 这项研究揭示了Drosophila中的上升性基因组神经元 (AHN) 如何充当预测性CDC,将运动指令与适应性行为的感官处理集成在一起.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 感官处理 感官处理
背景情况:
- 自然行为依赖于区分自我诱导 (反应) 和外部 (消极) 感官输入.
- 附带放电电路 (CDC) 对于这种差异化至关重要,它使用运动信号来预测感官后果.
- 疾病预防控制中心的综合神经集成在很大程度上仍未被描述.
研究的目的:
- 为了阐明Drosophila中上升的基因组神经元 (AHN) 的网络架构和功能,作为预测性CDC.
- 研究AHN如何集成下降电机命令,并向下游的感觉和电机网络投射.
主要方法:
- 连接学,神经解剖学追踪,体内Ca2+成像和Drosophila的行为记录.
- 下降神经元的光遗传学操纵 (DNg02) 和AHN激活.
- 分析AHN与感官和运动处理中心的连接.
主要成果:
- 两对AHN从下降的神经元接收输入,特别是DNg02,它控制了机翼运动输出.
- AHN激活与飞行行为相关,并且在飞行行为之前,由下降命令触发.
- 每一对AHN都针对不同的下游感觉 (视觉,听觉,机械感觉) 和运动 (翼,,腿) 网络.
结论:
- 果 AHN 作为预测性CDC,将运动指令传递给感觉和运动系统.
- 这种信号机制很可能通过预测自我诱导的感官反来支持自适应感官运动控制.
- 不重叠的下游预测表明每个AHN对在调节不同的感觉和运动电路方面都有专门的角色.
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