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在人类血中测定levodropropizine的绿色和发明性的光方法

Islam M Mostafa¹, Mahmoud A Omar², Mohamed Ahmed Elsayed³

¹Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61511, Egypt; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

|February 25, 2024

概括

一种新,快速和敏感的度法准确地量化了人体血和药片中的levodropropizine (LVP). 这种绿色分析技术为制药和临床应用提供可靠的检测极限.

科学领域:

分析化学分析化学
药品分析药品分析
生物化学测试生物化学测试

背景情况:

利沃特胺 (LVP) 是一种广泛使用的抗咳药物.
在生物矩阵中精确量化LVP对于药理动力学和治疗药物监测至关重要.
现有的分析方法可能缺乏灵敏度,速度或环保性.

研究的目的:

开发和验证一种绿色,快速和灵敏的度测量方法,用于量化levodropropizine.
评估该方法在人体血和制药配方中确定LVP的适用性.

主要方法:

在蒸水中利用了levodropropizine的内在光.
在240nm处激发,在345nm处检测排放.
验证了该方法的线性,检测极限,量化极限,以及在血和药片中的回收.

主要成果:

该方法在501000 ng/mL的度范围内显示出出色的线性.
达到0.77 ng/mL的低检测极限和2.33 ng/mL的量化极限.
获得的高平均恢复率为98.64±1.07%在药片中和98.68100.14%在人类血中.

结论:

开发的度测量方法是可靠的,敏感的和高效的levodropropizine量化.
这种绿色分析方法适用于药品质量控制和临床研究中对LVP的常规分析.
该方法为药理动力学研究和levodropropizine治疗药物监测提供了有价值的工具.

关键词:

度测量法度测量法内在的光是一种内在的光.莱沃德罗普罗皮津 (Levodropropropizine) 是一种药物.尖的人类血.药片药片药片药片

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