酸修饰的阿塔普尔吉特含有巴西洛米辛D,用于抑制模具和去除真菌毒素
Jing Sun1, Zaixu Wang1, Yongjin Dai1
1College of Food Science and Engineering/Collaborative, Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing, Nanjing University of Finance and Economics, Nanjing 210023, China.
Food chemistry
|February 25, 2024
概括
荷载在酸修饰的阿塔普尔吉特 (H-ATP) 上的巴西洛米辛D (BD) 制造了一种新型复合材料. 这种H-ATP-BD复合物有效地抑制了菌生长,并消除了亚毒素B1,为健康威胁提供了一种绿色解决方案.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 食品安全 食品安全
背景情况:
- 模具和真菌毒素对健康构成重大风险.
- 巴西洛米D (BD) 是一种有效的抗真菌剂.
- 阿塔普尔吉特 (ATP) 可以作为抗菌化合物的载体.
研究的目的:
- 开发一种新型的复合材料 (H-ATP-BD) 通过将巴西洛米辛D加载到酸修饰的阿塔普尔吉特 (H-ATP) 上.
- 为了评估H-ATP对BD的吸附性能.
- 评估H-ATP-BD复合物的抗真菌和毒素降低能力.
主要方法:
- 通过酸性修饰天然的阿塔普尔吉特 (ATP) 来获得H-ATP.
- 在H-ATP上加载Bacillomycin D (BD),形成H-ATP-BD复合物.
- 使用FTIR,XRD,XPS进行表征,并分析尺寸和泽塔潜力.
- 评估模具抑制和阿弗拉托克辛B1 (AFB1) 清除效率.
主要成果:
- 与ATP相比,H-ATP表现出比BD更好的吸附能力,达到93.13%的吸附率.
- 描述技术证实了BD在H-ATP上成功加载.
- 该H-ATP-BD复合物表现出对阿斯伯吉路斯菌的显著抑制.
- 该复合物在50°C时有效地去除了89.06%的亚毒素B1,去除是一种自发的外热过程.
结论:
- 开发的H-ATP-BD复合物是一种高效的抗微生物和减少毒素的材料.
- 经酸修饰的阿塔普尔吉特增强了巴西洛米辛D的负载.
- 这项研究为开发用于菌和真菌毒素控制的绿色和有效材料提供了基础.
相关概念视频
01:27Microbial Leaching
238
Microbial leaching, also known as bioleaching, is an environmentally favorable method for extracting metals from low-grade ores using specific microorganisms. This biotechnological approach is particularly valuable for mining operations targeting copper, gold, and uranium, where traditional extraction methods may be economically or environmentally impractical.Copper Leaching and Microbial CatalysisIn copper bioleaching, crushed ore is arranged into heaps and irrigated with a dilute sulfuric...
238
01:19Acid Mine Drainage
123
Mining activities that disturb sulfide-rich rocks, particularly those containing pyrite (FeS₂), initiate a cascade of geochemical and microbiological processes with serious environmental implications. When exposed to air and water, pyrite undergoes oxidation, releasing sulfate, ultimately forming sulfuric acid and mobilizing heavy metals into surrounding water systems. This phenomenon, known as acid mine drainage (AMD), results in low pH waters laden with toxic elements that threaten...
123
01:18Production of Biopesticides
120
Biopesticides offer a sustainable alternative to chemical pesticides, utilizing microbial agents to control agricultural pests. Bacillus thuringiensis (Bt) is a widely employed bacterium known for its potent insecticidal activity. Bt biopesticides are favored for their specificity to insect pests, minimal environmental impact, and natural degradability.Mechanism of Bt Toxin Action Bt produces insecticidal crystal (Cry) proteins during its sporulation phase. These proteins form parasporal...
120
01:15Antifungal Agents
131
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
131