大规模分析揭示了结核病进展和预后的拼接生物标志物
Hongli Lai1, Mengyuan Lyu2, Hongxia Ruan2
1Department of Laboratory Medicine/Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, PR China; West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, PR China.
Computers in biology and medicine
|February 25, 2024
概括
异常的替代拼接 (AS) 显示了预测结核病 (TB) 结果的潜力. 特定的AS事件可以预测结核病预后,为疾病管理提供新的生物标志物.
科学领域:
- 基因组学就是基因组学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 异常的替代拼接 (AS) 越来越多地与结核病 (TB) 有关.
- 在预测结核病进展和预后方面,AS的作用需要进一步澄清.
研究的目的:
- 研究AS事件作为TB进展和预后的生物标志物的潜力.
- 使用机器学习开发结核病结果的预测模型.
主要方法:
- 对结核病进展和预后的公共RNA-seq数据集的分析.
- 使用百分比分成 (PSI) 和SUPPA2.2.使用AS事件的量化.
- 使用多种机器学习方法开发和评估预测模型.
主要成果:
- 三个AS事件 (GET1-SE,TPD52-AF,TIMM10-A5) 对结核病进展的预测价值有限.
- 五个AS事件 (PHF23-AF,KIB1B-SE,MACROD2-A3,CD55-RI,GALNT11-AF) 被确定为结核病预后的候选生物标志物.
- 整合了这五个事件的XGBoost模型在训练组中实现了0.875的AUC,在测试组中达到0.805.
结论:
- 特定的AS事件,特别是PHF23-AF,KIB1B-SE,MACROD2-A3,CD55-RI和GALNT11-AF,显示出预测结核病预后的希望.
- 这些AS事件代表了TB结果预测的潜在生物标志物.
- 需要进一步的研究来验证这些发现并探索它们的临床实用性.
相关概念视频
01:26Pulmonary Tuberculosis IV
143
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
143
01:32RNA Splicing
56.4K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
56.4K
01:31Pulmonary Tuberculosis III
326
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
326