儿科患者的内分泌相关不良状况治疗免疫检查点抑制恶性瘤的治疗
1The Jesse Z. and Lea Shafer Institute of Endocrinology and Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Hormone research in paediatrics
|February 25, 2024
概括
儿童癌症患者可能会因为免疫检查点抑制剂 (ICI) 而出现与免疫相关的内分泌异常. 这些不良事件的早期发现和管理对于有效的治疗和支持性护理至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 癌症免疫疗法取得了显著的进步,免疫检查点抑制剂 (ICI) 在成人癌症治疗中变得至关重要.
- 儿科对ICI的经验有限,但在不断增长.
- 免疫相关不良事件 (irAEs) 是已知的ICI并发症.
研究的目的:
- 审查接受ICI的儿科患者免疫相关内分泌病的当前数据.
- 为这些不良事件的管理提供建议.
主要方法:
- 关于儿童群体ICI和内分泌病的研究的文献综述.
- 报告病例的分析和临床指导方针.
主要成果:
- 免疫相关的内分泌病变,包括甲状腺功能障碍,糖尿病,上腺功能不充分和垂体功能不充分,已在ICI的儿科患者中报告.
- 这些事件很可能是由于免疫系统过度激活.
结论:
- 临床医生必须注意ICI治疗的儿科患者潜在的免疫相关内分泌病变.
- 早期诊断,监测和及时治疗对于最佳的支持性护理和儿童的持续ICI治疗至关重要.
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