生命早期的压力和肠道微生物组:基于人口的全面调查
Rosa H Mulder1, Robert Kraaij2, Isabel K Schuurmans1
1Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Brain, behavior, and immunity
|February 25, 2024
概括
早期生活中的社会经济压力,而不是整体的早期生活压力,与儿童的肠道微生物群不那么多样化有关. 这种联系可能受到饮食质量和体重指数 (BMI) 的影响.
科学领域:
- 微生物组研究 微生物组研究
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 早期生活压力 (ELS) 与不良健康结果有关.
- 肠道微生物组在与压力相关的健康问题中的作用正在调查中,人类数据有限.
- 以前对ELS和肠道微生物群的人类研究经常使用小的,精选的样本和追溯ELS报告.
研究的目的:
- 为了检查预期的早期生活压力 (ELS) 和肠道微生物群在一个大规模的,基于人口的儿童队列之间的关联.
- 调查整体ELS和五个ELS域对肠道微生物群的独特影响.
- 探索饮食和体重指数 (BMI) 在ELS-微生物组关联中的潜在调解作用.
主要方法:
- 在2,004名儿童中从出生到10岁的ELS的前性测量 (R世代研究).
- 在10岁时使用16S rRNA测序分析便微生物组,评估多样性 (α和β多样性) 和预测功能途径.
- 调解者的探索:饮食质量,促炎症饮食,纤维摄入量和8岁和10岁的BMI.
主要成果:
- 经过多次测试校正后,在整体ELS和肠道微生物群之间没有发现显著的关联.
- 背景风险 (社会经济压力) 与微生物群的变异性有显著的关联,包括较低的α-多样性和改变的β-多样性.
- 背景风险与预测的功能途径有关,包括托生物合成,其中的关联部分由饮食质量,促炎饮食,纤维摄入量和BMI调解.
结论:
- 社会经济逆境,特别是早期生活中的情境风险,与儿童的肠道微生物群差异较小有关.
- 背景风险和微生物组之间的观察到的关联可能部分由饮食质量和BMI解释.
- 需要进一步的研究来确定因果关系,并调查饮食干预措施是否可以减轻社会经济逆境对微生物群的负面影响.
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