对下一代测序/综合基因组分析的价值标准进行系统审查,以告知价值框架的发展
Federico Augustovski1, Carla Colaci1, Mackenzie Mills2
1Health Technology Assessment and Health Economics Department, Institute for Clinical Effectiveness and Health Policy (IECS).
概括
这项研究确定了评估下一代测序/综合基因组分析 (NGS/CGP) 的综合价值标准. 这些发现有助于医疗保健决策和患者获得有价值的技术.
科学领域:
- 卫生经济学和结果研究研究.
- 基因组医学是一种基因组医学.
- 卫生技术评估 卫生技术评估
背景情况:
- 价值框架 (VF) 对于评估医疗保健技术至关重要.
- 现有的VF通常缺乏针对下一代测序/综合基因组分析 (NGS/CGP) 等先进诊断的特异性.
- 需要采用协调的方法,以确保对NGS/CGP的一致评估.
研究的目的:
- 确定和绘制NGS/CGP评估的价值标准.
- 开发一个多利益相关者NGS/CGP价值框架的基础.
- 帮助医疗保健决策和改善患者获得高价值的基因组技术.
主要方法:
- 对医疗保健技术现有价值框架 (VF) 的系统审查.
- 映射确定了VF和标准,并将其与拉丁美洲 (LA) 的VF进行协调.
- 为NGS/CGP.提取和综合基于证据的标准和子标准.
主要成果:
- 分析了42个额外的VF,其中88%来自高收入国家.
- 总共提取了242个标准和子标准,并增加了15个新标准.
- 临床益处和经济方面是最常见的标准;确定了18个标准和36个子标准.
结论:
- 建立了一套基于证据的医疗保健决策标准和子标准.
- 这些发现支持开发一个全面的NGS/CGP价值框架.
- 这项工作可以改善患者获得高价值健康技术的机会.
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