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在定时空隙中测量的和可以用作验证自我报告仪器的参考仪器吗? 尿液校准研究的结果
Laurence S Freedman1, Chia-Yih Wang2, John Commins3
1Information Management Services Inc., Rockville, MD, United States; Biostatistics and Biomathematics Unit, Gertner Institute for Epidemiology and Health Policy Research, Chaim Sheba Medical Center, Ramat Gan, Israel.
The American journal of clinical nutrition
|February 25, 2024
概括
定时的尿空可以取代24小时的收集,以验证饮食摄入量. 特定的定时空气组合准确地估计了和水平,为营养研究提供了切实可行的替代方案.
科学领域:
- 营养科学 营养科学
- 生物标志物开发 生物标志物开发
- 临床研究 临床研究
背景情况:
- 24小时尿液采集是验证饮食摄入量的标准.
- 自我报告的饮食摄入量仪器需要可靠的参考测量.
- 目前用于尿路和分析的方法可能是繁的.
研究的目的:
- 评估定时尿空是否可以作为替代参考测量.
- 为了确定空洞的最佳数量和时间,以准确评估和.
- 为了比较定时空洞与24小时收集在验证饮食回忆中的有效性.
主要方法:
- 在一项尿液校准研究中利用了441名成年人 (18-39岁) 的数据.
- 收集了24小时的尿液和定时的空隙 (早上,下午,晚上,一夜之间).
- 采用线性回归来预测24小时尿液中的/从定时空隙中,调整为共变量.
主要成果:
- 确定了最佳组合:单次 (晚上),配对 (下午+夜间;早上+晚上) 和三重空洞 (早上+晚上+夜间;早上+下午+晚上).
- 预测的24小时尿液水平准确地估计了饮食回忆偏差,但精度降低.
- 需要增加样本大小 (1.5-2.7倍),以匹配24小时采集的精度.
结论:
- 定时尿空提供了一个可行的替代方案,用于参考测量24小时收集.
- 这些发现支持开发使用定时空隙的新型参考生物标志物.
- 进一步的研究可以完善时间空白协议,以改善饮食评估验证.
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