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Updated: Jul 2, 2025

LERLIC-MS/MS for In-depth Characterization and Quantification of Glutamine and Asparagine Deamidation in Shotgun Proteomics
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同类学建模和分子对接研究,以减少Yarrowia lipolytica L-asparaginase的谷氨酸亲和力.

Farshad Darvishi1, Elham Beiranvand2, Hourieh Kalhor3

  • 1Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran; Research Center for Applied Microbiology and Microbial Biotechnology (CAMB), Alzahra University, Tehran, Iran.

International journal of biological macromolecules
|February 25, 2024
PubMed
概括

研究人员修改了Yarrowia lipolytica L-asparaginase (YL-ASNase) 来改善白血病的治疗方法. 特定突变显著增加了L-阿斯巴拉金的亲和力,同时减少了L-氨酸的亲和力,可能降低了癌症治疗中的副作用.

关键词:
酶工程是什么?酶工程是什么?葡萄糖胺酶的活性活动.在L-asparaginase的使用中.分子对接是分子对接.雅罗维亚 (Yarrowia lipolytica) 是一个高脂的植物.

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