在再生牙科的干细胞:当前的理解和未来的方向
Pooja Shah1, Marziyeh Aghazadeh1, Sheeja Rajasingh1
1Department of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, USA.
Journal of oral biosciences
|February 25, 2024
概括
介质细胞干细胞 (MSCs) 显示出可以再生口腔组织的潜力,如牙和骨. 虽然动物研究令人鼓舞,但临床应用需要在再生牙科安全性和有效性的标准化协议.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 牙科研究 牙科研究
背景情况:
- 再生牙科利用细胞和基因疗法来恢复口腔组织的结构和功能.
- 介质细胞干细胞 (MSCs) 在再生牙科中显示出显著的潜力,一些疗法已进入临床试验.
- 本综述综合了对MSC用于治疗应用的动物研究,解决了从临床前研究向临床实践的过渡.
研究的目的:
- 审查用于再生牙科应用中介质干细胞 (MSC) 的动物研究.
- 分析纸-牙,气膜骨和牙周再生的方案和结果.
- 确定MSC疗法临床实施的挑战和转化方面.
主要方法:
- 在再生牙科中涉及MSCs的动物研究的全面审查.
- 对研究的分析,重点是乳皮-牙,气膜骨和牙周再生.
- 检查各种MSC类型 (牙科衍生,骨髓,带) 和它们的应用.
主要成果:
- MSCs在硬组织重建,肉再生,根延长和牙周组织形成方面已经证明有效.
- 应用包括根管治疗,牙周缺陷修复,口保护和鼻提升.
- 在各种临床前模型中观察到牙和牙周组织的成功再生.
结论:
- 基于细胞的治疗方法用于牙和牙周的再生仍处于早期发展阶段.
- 遵守良好制造实践的标准化协议对于可重复性,安全性和成本效益至关重要.
- 在再生牙科中,细胞治疗提供了显著的好处,但在实现可持续的,长期的口腔组织再生方面面临着挑战.
相关概念视频
01:21Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
01:17Stem Cell Culture
5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.2K
01:27Source And Potency Of Stem Cells
4.8K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
4.8K
01:19Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
00:58Embryonic Stem Cells
27.5K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
27.5K
01:13Induced Pluripotent Stem Cells
22.9K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
22.9K