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Carlo Eikani¹, Aaron Hoyt², Elizabeth Cho²

¹Loyola University Stritch School of Medicine; Department of Orthopaedic Surgery & Rehabilitation, Loyola University Medical Center, 2160 South 1st Avenue, Maguire Suite 1700, Maywood, IL, USA.

The Orthopedic clinics of North America

|February 25, 2024

概括

与骨折相关的感染在骨科创伤中构成了重大挑战,导致频繁的手术. 当地抗生素的输送越来越多地用于改善风险骨折的结果.

科学领域:

骨科创伤的创伤是什么
传染病管理传染病管理
生物材料科学生物材料科学

背景情况:

骨折相关感染 (FRIs) 是骨科创伤的严重并发症,通常需要多次手术干预.
目前的标准护理,包括全身抗生素和手术,治疗失败率高达35%.

研究的目的:

审查当前和新兴的临床策略,用于局部抗生素在管理风险骨折.
突出局部抗微生物方法在骨科创伤中的演变和潜力.

主要方法:

对临床实践的文献综述和对骨折局部抗生素输送的新研究.
分析各种输送系统,包括粉末,聚甲基甲酸 (PMMA),生物降解材料,涂层植入物,水凝和纳米粒子.

主要成果:

局部抗生素的管理是一个日益增长的临床策略,以打击FRIs.
已建立的方法包括抗生素粉末,PMMA和涂层植入物.
像水凝和纳米颗粒这样的新兴技术显示出增强本地抗生素输送的未来前景.

结论:

局部抗生素输送为风险骨折的全身治疗提供了一个有希望的辅助或替代方案.
对新型传递系统的持续研究对于改善FRI治疗结果至关重要.
优化局部抗生素策略可能会减少手术干预和骨科创伤治疗失败.

关键词:

有抗生素涂层的植入物.与骨折相关的感染.当地抗生素当地抗生素骨科创伤的创伤情况骨髓炎是一种骨质炎.

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